Pao-Sheng Chang is an early-career postdoctoral research fellow at the Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford. His research focuses on neuroimmunology, particularly the interactions between macrophage and sensory afferents associated with peripheral nerve injury in humans.
In 2024, he published his research in PAIN, a leading journal in the field, identifying a distinct population of glucocorticoid-induced macrophages (MGC) within affected nerve tissues from patients with Morton's neuroma. Since 2025, sponsored by funding from the Guarantors of Brain, he has been developing a human-derived microfluidic platform to model the human peripheral sensory nervous system. Using high-sensitive GCaMP calcium imaging, his research aims to investigate how MGC influence the excitation of human sensory neurons.
In parallel, he employs single-cell RNA sequencing to characterize the cellular composition and cell–cell interactions within injured or chronically inflamed human nerve tissues, compared with uninjured nerve tissues. Ultimately, his research seeks to advance our understanding of neuroimmune interactions in human peripheral nerve injury and chronic pain, paving the way for the development of macrophage-targeted therapeutic strategies for nerve injury and pain management.
